Gastrin, acid, and bile.

Diet and Excretionof Bile Acid&

Reddy and Wynder (13) investigated fecal bile acids and neutral sterols of various population groups: North Americans consuming a high-fat, mixed western diet; North American Seventh-Day Adventists consuming a diet without meat and moderately low amount of fat; Japanese on a low-fat diet; Chinese consuming low-fat Chinese diet; and strict vegetarians consuming a low-fat vegetarian diet. A signi...

Pregnancy and bile acid disorders.

During pregnancy, extensive adaptations in maternal metabolic and immunological physiology occur. Consequently, preexisting disease may be exacerbated or attenuated, and new disease susceptibility may be unmasked. Cholestatic diseases, characterized by a supraphysiological raise in bile acid levels, require careful monitoring during pregnancy. This review describes the latest advances in the kn...

Bile Acid Induced Diarrhoea

Bile Acid Synthesis

During biosynthesis of bile acid, carbons 25-26-27 are removed from the cholesterol side-chain. Side-chain oxidation begins either with hydroxylation at the 26-position, in which case the three-carbon fragment is released as propionic acid, or with hydroxylation at the 25-position, in which case the threecarbon fragment is released as acetone. We have previously shown in the rat that the contri...

Managing bile acid diarrhoea.

Bowel symptoms including diarrhoea can be produced when excess bile acids (BA) are present in the colon. This condition, known as bile acid or bile salt malabsorption, has been under recognized, as the best diagnostic method, the (75)Se-homocholic acid taurine (SeHCAT) test, is not available in many countries and is not fully utilized in others. Reduced SeHCAT retention establishes that this is...